Anthropic says it has produced the first three-dimensional structure of a vault particle found in prokaryotic cells. Its Claude model contributed to the literature search, the optimization of methods for isolating the particles and the mapping of their three-dimensional shape. Tasks that would normally take weeks or months were reduced to a few days, while human oversight remained necessary to correct model errors. The structure elucidates a large, hollow protein barrel known since 1986, but its biological function remains undetermined. It may nevertheless provide clues about cellular transport and stress responses in both prokaryotic and eukaryotic organisms.
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